After a failed marriage, engineer Hector Belascoaran Shayne (Sergio Goyri) decides to fulfill his wish of becoming a private detective. He learns about a serial strangler who leaves a trail of dead bodies, soon after, the psychopath begins taunt him with intimidating notes. A cat-and-mouse game unfolds.
"La Nueva Jerusalem" is a small community of believers lead by Papá Basilio (Rabal) and Mamá Dorita (Jurado). They're waiting for the second coming of Christ, so they've abandoned the world, searching for a new spiritual life. Mamá Dorita sees in young Tomasa (Gurrola) the signals of the chosen one. The young girl will be the new leader in "La Nueva Jerusalem".
埃斯科瓦尔(瓦格纳·马拉 Wagner Moura 饰)曾是一个走私商人,机缘巧合之下开始接触毒品生意,野心勃勃的他将无法计数的毒品贩卖到美国,成为了富可敌国的大毒枭。与此同时,他集结了圈内几大巨头,成立了声名显赫的麦德林集团,一时间,埃斯科瓦尔的劲头无人能敌。
墨菲(波伊德·霍布鲁克 Boyd Holbrook 饰)是美国缉毒局派往哥伦比亚的警探,他和搭档潘那(佩德罗·帕斯卡 Pedro Pascal 饰)合作,主要负责埃斯科瓦尔的案件。埃斯科瓦尔当上了议员,甚至决心竞选总统,却在国会当众受辱。之后,哥伦比亚**试图启用引渡法案对付毒枭们,为了对抗**,埃斯科瓦尔彻底沦为了反社会的恐怖分子,在不断壮大自己的毒品帝国的同时,用炸弹、暗杀和鲜血提醒着哥伦比亚**,谁才是真正的老大。